Given that Tony Stark died using the Infinity Gauntlet to wipe out Thanos and his forces in Avengers: Endgame, I suspect that Victor von Doom, who, like Tony, is incredibly intelligent, but doesn’t have any superpowers, wouldn’t survive either. That being said, if Doom was able to plan ahead, it’s possible he could invent a machine that allows his body to endure the energy of the Infinity Stones. Still, if Thanos and Hulk weren’t able to walk away from using that power unscathed, it’s hard to imagine Doom would either.
Article source: https://www.cinemablend.com/news/2551827/doctor-doom-wields-the-infinity-gauntlet-in-awesome-art-from-marvel-studios-designer