In Avengers: Age of Ultron, Natasha revealed to Bruce that she couldn’t have her own children, since she was sterilized as part of her spy initiation. The scene caused some controversy, but it would’ve been an interesting tie-in to see Natasha caring for so many children years later. In a way, it could’ve been like she’d adopted the Thanos orphans.
Article source: https://www.cinemablend.com/news/2471648/avengers-endgame-originally-gave-black-widow-a-heartbreaking-new-job